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From "Dligach, Dmitriy" <ddlig...@luc.edu>
Subject Re: Phenotype-specific entities [SUSPICIOUS] [SUSPICIOUS]
Date Wed, 15 Feb 2017 21:14:59 GMT
Very nice! Thank you, Tim and Sean.


> On Feb 15, 2017, at 13:25, Miller, Timothy <Timothy.Miller@childrens.harvard.edu>
> Lol was just about to send this:
> https://github.com/tmills/umls-graph-api
> It points at your umls META directory, reads in the ctakes list of TUIs, and builds a
neo4j graph database with all the ISA links, and has a simple API for getting parent/child
> I used it for coreference.
> Tim
> ________________________________________
> From: Finan, Sean <Sean.Finan@childrens.harvard.edu>
> Sent: Wednesday, February 15, 2017 2:23 PM
> To: dev@ctakes.apache.org
> Subject: RE: Phenotype-specific entities [SUSPICIOUS] [SUSPICIOUS]
> The dictionary gui doesn't walk the ontology.  There are umls tables that list relations,
wherein things like "isa" (is a) relations may satisfy a hypernym requirement.  If you have
the umls rrf files look at mrrel.rrf.  The structure is basically concept1|..| concept2|..|relationtype|..
  See section 3.3.9: https://urldefense.proofpoint.com/v2/url?u=https-3A__www.ncbi.nlm.nih.gov_books_NBK9685_&d=DwIFAg&c=qS4goWBT7poplM69zy_3xhKwEW14JZMSdioCoppxeFU&r=Heup-IbsIg9Q1TPOylpP9FE4GTK-OqdTDRRNQXipowRLRjx0ibQrHEo8uYx6674h&m=agwhlSpSUQ0H6VeJpnACDGcka2fVYSy3HaITKaJN9S8&s=aODQU20_0mAv1i_izwB3RZGOBB0U0ZucFkByxovUJJc&e=
> If anybody has made anything that parses/uses umls relations and can be used by ctakes,
please contribute!  Something like a simple traversable umls graphdb would be a great addition
...  Even if it is incomplete or rough, it could be a valuable seed for a new effort.
> Sean
> -----Original Message-----
> From: Savova, Guergana [mailto:Guergana.Savova@childrens.harvard.edu]
> Sent: Wednesday, February 15, 2017 1:54 PM
> To: dev@ctakes.apache.org
> Subject: RE: Phenotype-specific entities [SUSPICIOUS]
> I don't believe there is a tool for walking the UMLS ontology, Dima. But Sean should
confirm that his dictionary building tool does not have that functionality.
> I think you can use the UMLS tables to get that information. It has been quite a while
I have used these tables, but I remember I was able to get that information from them...
> Sean,
> Does your dictionary building tool implement ontology walking?
> --Guergana
> -----Original Message-----
> From: Dligach, Dmitriy [mailto:ddligach@luc.edu]
> Sent: Wednesday, February 15, 2017 1:50 PM
> To: dev@ctakes.apache.org
> Subject: Re: Phenotype-specific entities
> Guergana, thank you.
> Is there anything in cTAKES now for walking the UMLS ontology (e.g. for finding hypernyms,
synonyms, etc.)?
> Dima
>> On Feb 15, 2017, at 12:45, Savova, Guergana <Guergana.Savova@childrens.harvard.edu>
>> Hi Erin,
>> Yes, creating your customized dictionary is the way to go. You can prune by semantic
types of interest and then remove branches that are not relevant to your specific phenotype.
I am not aware of cTAKES implementing such a tool for a very customized dictionary.
>> You can also start with  a few terms that you know are relevant to your phenotype
and then find their synonyms in the UMLS. Then, you can further walk a specific ontology and
take siblings, parents if you think they are relevant.
>> Then, there is the whole field of using word embeddings to find synonyms/related
terms from unlabeled data  if you want to become really fancy :-) At this point, cTAKES does
not implement any deep learning algorithms, in the future we are planning to release a bridge
>> I hope this makes sense.
>> --
>> Guergana Savova, PhD, FACMI
>> Associate Professor
>> PI Natural Language Processing Lab
>> Boston Children's Hospital and Harvard Medical School
>> 300 Longwood Avenue
>> Mailstop: BCH3092
>> Enders 144.1
>> Boston, MA 02115
>> Tel: (617) 919-2972
>> Fax: (617) 730-0817
>> Guergana.Savova@childrens.harvard.edu
>> Harvard Scholar: https://urldefense.proofpoint.com/v2/url?u=http-3A__scholar.harvard.edu_guergana-5Fk-5Fsavova_biocv&d=DwIFAw&c=qS4goWBT7poplM69zy_3xhKwEW14JZMSdioCoppxeFU&r=SeLHlpmrGNnJ9mI2WCgf_wwQk9zL4aIrVmfBoSi-j0kfEcrO4yRGmRCJNAr-rCmP&m=EMsbVKH4fuTPUXGVRWfjw4vqV3ifyKdh-3K3OLUIogI&s=oAz3p_diNUmQdKL6UIfE9Vsnj1T4H5xq6CIof1jXisU&e=
>> ctakes.apache.org
>> thyme.healthnlp.org
>> cancer.healthnlp.org
>> share.healthnlp.org
>> -----Original Message-----
>> From: Erin Nicole Gustafson [mailto:erin.gustafson@northwestern.edu]
>> Sent: Wednesday, February 15, 2017 1:38 PM
>> To: dev@ctakes.apache.org
>> Subject: Phenotype-specific entities
>> Hi all,
>> I would like to be able to only identify entities that are relevant for some specific
phenotype. One step towards achieving this would be to build a custom dictionary with a limited
set of semantic types. However, this is not quite specific enough to only identify mentions
related to one disease while ignoring those related to some other disease, for example.
>> Does cTAKES currently have a way to do this sort of filtering? Or, has anyone developed
their own tools that they'd be willing to share?
>> Thanks,
>> Erin

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