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From "Hari, Sekhar" <sekhar.h...@cgi.com>
Subject FW: Drug-Allergy Contraindications [EXTERNAL]
Date Fri, 08 Dec 2017 13:09:53 GMT
Hi -

I' m looking to build a drug-allergy alert system. For example, for a Type A adverse drug
reactions (e.g. 'Patient is allergic to Penicillin') - so we take in parameters for the allergy
(Penicillin) and the drug (Amoxicillin), and returns a warning saying not to prescribe it.
Do we have anything pre-built which can be reused? Please see the email from Sean below.

Thanks
Sekhar H

-----Original Message-----
From: Finan, Sean [mailto:Sean.Finan@childrens.harvard.edu] 
Sent: 07 December 2017 22:50
To: Hari, Sekhar
Subject: RE: Drug-Allergy Contraindications [EXTERNAL]

Hi Sekhar H.,

Ah - that is very different from a database containing reported drug allergies.  Ctakes does
not do that as-is.  You would need to implement a component that compares the discovered medication
allergies and the prescribed medications and then displays a warning.  Somebody may have one
pre-built that you can reuse.  Otherwise it should be fairly easy to implement a rough version
using section types and cui proximities, perhaps with a dash of regex for a bolder flavor.
 However, I would post to the dev list to see if anybody has something that would work for
you.

Sean

-----Original Message-----
From: Hari, Sekhar [mailto:sekhar.hari@cgi.com] 
Sent: Thursday, December 07, 2017 11:23 AM
To: Finan, Sean
Subject: RE: Drug-Allergy Contraindications [EXTERNAL]

I'm talking about type A adverse drug reactions (e.g. 'Patient is allergic to Penicillin'
- so we take in parameters for the allergy (Penicillin) and the drug (Amoxicillin), and returns
a warning saying not to prescribe it). Can cTAKES do this?

Thanks
Sekhar H.

-----Original Message-----
From: Finan, Sean [mailto:Sean.Finan@childrens.harvard.edu] 
Sent: 07 December 2017 18:41
To: Hari, Sekhar
Cc: dev@ctakes.apache.org; user@ctakes.apache.org
Subject: RE: Drug-Allergy Contraindications [EXTERNAL]

I think that you are talking about metabolic genetics.  That isn't the same thing, though
there may be information in the fda drug/event or food/event, for instance for gum and soft
drinks for phenylketonuria (PKU).  But There may be a better way to get that information.
Gene Ontology (GO) or Human Phenome Ontology (HPO)?

Sean

-----Original Message-----
From: Hari, Sekhar [mailto:sekhar.hari@cgi.com] 
Sent: Thursday, December 07, 2017 8:04 AM
To: Finan, Sean
Cc: dev@ctakes.apache.org; user@ctakes.apache.org
Subject: RE: Drug-Allergy Contraindications [EXTERNAL]

Thank you so much. I will check that.

Just a question out of my curiosity - are Drug-Allergy (the so called ADR) the same as Drug-Gene
interactions (for example: immunological reactions caused by a gene due to a particular drug
substance)?

Thanks,
Sekhar H.

-----Original Message-----
From: Finan, Sean [mailto:Sean.Finan@childrens.harvard.edu] 
Sent: 07 December 2017 18:30
To: dev@ctakes.apache.org; user@ctakes.apache.org
Subject: RE: Drug-Allergy Contraindications [EXTERNAL]

Hi Sekhar H.,

You could check out the downloads at openfda.gov

https://urldefense.proofpoint.com/v2/url?u=https-3A__open.fda.gov_downloads_&d=DwIFAg&c=qS4goWBT7poplM69zy_3xhKwEW14JZMSdioCoppxeFU&r=fs67GvlGZstTpyIisCYNYmQCP6r0bcpKGd4f7d4gTao&m=iaiNRnm2HC44M__BYtKd7n-ykF_rhlKbAMBXpvpx73A&s=u7jx7Tlezy5T_AsqaB6MWeBAfoVPik_F5LZ3ukwwHZU&e=

The json files in food/event and drug/event might help.

Sean 

-----Original Message-----
From: Hari, Sekhar [mailto:sekhar.hari@cgi.com] 
Sent: Thursday, December 07, 2017 7:38 AM
To: user@ctakes.apache.org; dev@ctakes.apache.org
Subject: Drug-Allergy Contraindications [EXTERNAL]

Hi -

Is anybody aware of a database that stores all reported drug-allergy contraindications?

Thanks,
Sekhar H.


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