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From "Finan, Sean" <Sean.Fi...@childrens.harvard.edu>
Subject Re: Therapeutic are - Drug mapping [EXTERNAL]
Date Tue, 19 Mar 2019 14:59:45 GMT
Hi Sekhar,

I think that the treatment relations that might interest you most would be "manages", "treats",
"prevents".  Then follow the "isa" relations up until you find a root area (disease / finding)
of interest.

Walking the semantic web can be a little challenging, as not every node that has a relationship
will list it explicitly.  For instance, aspirin is used for a lot of things, but might have
zero "manages" relations.  Instead, an ancestor of aspirin like "non-steroidal drug" might
have the relations.

Unless you have some experience with graphs and the umls then it might be better for you to
use some other existing dataset or api.

good luck,
Sean
________________________________________
From: Hari, Sekhar <sekhar.hari@cgi.com>
Sent: Tuesday, March 19, 2019 7:17 AM
To: dev@ctakes.apache.org
Subject: RE: Therapeutic are - Drug mapping [EXTERNAL]

Thanks Sean! Looks a little complex to navigate the relationships. Can you please cite the
most appropriate terms in this relationship that may point to therapeutic area?

Thanks
Sekhar Hari | AI Program Lead | Health Sciences R&D | Asia Pacific Solutions Delivery
Center
+91 814 7027 779 (C)


-----Original Message-----
From: Finan, Sean <Sean.Finan@childrens.harvard.edu>
Sent: Monday, March 18, 2019 11:09 PM
To: dev@ctakes.apache.org
Subject: Re: Therapeutic are - Drug mapping [EXTERNAL]

Hi Sekhar,

Perhaps through relationships in the umls you could arrive at such groupings.

https://urldefense.proofpoint.com/v2/url?u=https-3A__www.nlm.nih.gov_research_umls_META3-5Fcurrent-5Frelations.html&d=DwIFAg&c=qS4goWBT7poplM69zy_3xhKwEW14JZMSdioCoppxeFU&r=fs67GvlGZstTpyIisCYNYmQCP6r0bcpKGd4f7d4gTao&m=oRbKp1vdCyFhiA0FxL1-jWiPVkUi0tMecCn2kcoe1Vo&s=c9-O3_dlDm1ttSNgIgfUpUv2PpXIMDqG7jGNgjHysd8&e=

https://urldefense.proofpoint.com/v2/url?u=https-3A__www.ncbi.nlm.nih.gov_books_NBK9679_figure_ch05.F3_&d=DwIFAg&c=qS4goWBT7poplM69zy_3xhKwEW14JZMSdioCoppxeFU&r=fs67GvlGZstTpyIisCYNYmQCP6r0bcpKGd4f7d4gTao&m=oRbKp1vdCyFhiA0FxL1-jWiPVkUi0tMecCn2kcoe1Vo&s=nOPrRn_ujda8UOvwedQKkE32wmRNGqSJv0zA9cRcZnw&e=

Sean
________________________________________
From: Hari, Sekhar <sekhar.hari@cgi.com>
Sent: Monday, March 18, 2019 12:42 PM
To: dev@ctakes.apache.org
Subject: Therapeutic are - Drug mapping [EXTERNAL]

Hi -

Is there a publicly available database or API that can provide mapping between a therapeutic
area and drugs? For example: all the FDA approved drugs in use for the therapeutic area "Cardiovascular".

Thanks
Sekhar H.


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